In a previous study, Wei et al. showed the anti-inflammatory and immunodulatory effects of Exc-B in 12-O-Tetradecanoylphorbol-13-acetate (TPA) induced inflammation and dermatitis in murine skin, as well as in LPS-induced mouse bone marrow-derived dendritic cells, by reduction of IL-6 and TNF-α protein expression [37]. Here, IL6 is linked to skin disorder.