PTK2 and hepatocellular carcinoma: Finally, Zhang et al. [67], provided novel insights into the biological function of Galectin-1 signalling in HCC, demonstrating that the over-expression of this protein enhanced HCC invasion and sorafenib resistance by up-regulating the expression of αvβ3 integrin which, in turn, activated the FAK/PI3K/Akt pathway [67].