Among these pathways emerge the role of both Rab5a, a member of RAS oncogene family which is frequently overexpressed in HCC tissues in in vitro HCC experimental models [65], and of ERK5, which depletion blocks tumour growth in HCC xenografts and induces redistribution of FAK at focal contacts [66]. The gene discussed is RAB5A; the disease is hepatocellular carcinoma.