ADORA2A and Parkinson disease: We have shown that the activity of two major dopamine responsive neuronal cell types in the striatum, namely the direct and indirect pathway spiny projection neurons, is modulated by changes in expression and plasma membrane availability of the dopamine D1 and the adenosine A2a receptors, respectively [32,44] Both these receptors are primarily responsible for behavioral responses to dopamine and L-DOPA, therefore, we presume CK2 must have a role in Parkinson’s disease; this investigation is currently under way.