PACAP rescues DAergic neurons from neurodegeneration and improves motor alterations induced by unilateral 6-OHDA or MPTP injection in rat models of PD (Reglodi et al., 2004; Somogyvari-Vigh and Reglodi, 2004; Takei et al., 1998; Wang et al., 2008). This evidence concerns the gene ADCYAP1 and Parkinson disease.