Several lines of evidence indicate that the G6PD+202T allele has been under recent positive selection (Tishkoff et al., 2001; Sabeti et al., 2002; Tripathy and Reddy, 2007) and the main driving force for positive selection is thought to be heterozygote advantage against malaria in females (Bienzle et al., 1972; Luzzatto, 2015). Here, G6PD is linked to malaria.