G6PD and malaria: Evolutionary support for this hypothesis is provided by haplotype and sequence analyses indicating that G6PD variants have evolved independently, at a frequency that is inconsistent with random genetic drift, and over a period of time that is consistent with the estimated time since the emergence of malaria (Tishkoff et al., 2001; Sabeti et al., 2002; Saunders et al., 2002; Verrelli et al., 2002; Saunders et al., 2005).