In this paper, our findings indicate that CHB patients have an imbalanced IFN-γ/IL-4 ratio and that Th1/Th2 cytokines drift into a Th2 lymphocyte subcluster with the degree of liver fibrosis, suggesting that the imbalance of IFN-γ/IL-4 may be involved in the immunopathogenesis of CHB fibrosis. This evidence concerns the gene IL4 and Hepatic fibrosis.