IP-10 as a family member of non-ELR α-chemokines that binds to (C-X-C motif) receptor 3 (CXCR3) and participates in the IFN-mediated innate and specific immnune responses via promoting T helper (Th) 1 effector cells in response to IFN, plays a critical role in inflammation10, 11, 12, 13, 14, and is implicated in the development and progression of hepatic fibrosis. This evidence concerns the gene IFNA1 and Hepatic fibrosis.