The cut-off point for the serum IFN-γ/IL-4 ratio was also identified to be 1.8 (with the optimal Youden index), and this ratio revealed a sensitivity of 70.0%, a specificity of 72.9%, a positive predictive value of 80.2%, and a negative predictive value of 60.7% in predicting significant liver fibrosis. The gene discussed is IFNG; the disease is Hepatic fibrosis.