CXCL10 and Hepatic fibrosis: Furthermore, ROC curve analysis identified that a IP-10 level of 300 pg/mL was the most useful cut-off point (with the optimal Youden index) for predictive diagnosis of significant liver fibrosis, with a sensitivity of 92.7%, a specificity of 68.6%, a positive predictive value of 82.3%, and a negative predictive value of 85.7%.