IFNG and Hepatic fibrosis: Our studies have shown the positive correlation of IP-10 and the negative correlation of IFN-γ/IL-4 ratio with the degree of liver fibrosis in fibrotic CHB patients with score of 1–6, for which IP-10 in combination with the IFN-γ/IL-4 ratio significantly improved the discriminatory ability in predicting liver fibrosis.