Although we are the first to demonstrate that G6PI plays an important role in VEGF secretion from RASFs and mediate the hypoxia-induced angiogenesis in RA, it is consistent with Funasaka’s report that hypoxia-inducible VEGF regulates the PGI (phosphoglucose isomerase) expression, thereby enhances cancer cell motility32. The gene discussed is GPI; the disease is cancer.