However, in AND Tg mice lacking both DOCK8 and OSMR (Dock8−/−Osmr−/− AND Tg), scratching bouts per 2 h were reduced to 11.5±9.3, as compared with 200.8±135.8 in Dock8−/−Osmr+/− AND Tg mice (Fig. 3a), and they did not develop skin inflammation (Fig. 3b). The gene discussed is DOCK8; the disease is dermatitis.