Furthermore, given that switching the behaviour of PKM2 from a tetramer form to a dimer form increases the initial steps of tumour cell aerobic glycolysis and promotes tumour progression21, 32, we treated A549 cells with pTyr, a phosphotyrosine peptide that can promote PKM2 dimeric formation33, or fructose 1,6-bisphosphate (FBP) and serine, two molecules that enhance PKM2 tetrameric formation34. The gene discussed is PKM; the disease is neoplasm.