Either G-CSF mechanisms is activation of some immunological process that are responsible for implantation or it reacts via inducing inflammation, it seems that in patients with recurrent implantation failure who have good quality embryos and uterine cavity has no polyp, myoma, adenomyosis, or adhesion or any space occupying lesion or hydrosalpinx, G-CSF may increase pregnancy and implantation rates without serious side effects (42). This evidence concerns the gene CSF3 and adenomyosis.