VEGFA and primary congenital glaucoma: Mutations in CYP1B/1 are causative for Primary Congenital Glaucoma (reviewed in [21]), inhibition of CYP450 by stannous chloride reduced the inflammatory response in a closed eye contact lens rabbit model [22], and administration of siRNA targeting CYP4B1 inhibited corneal neovascularization in a suture-induced rabbit model by reducing production of 12-HETrE and inhibiting vascular endothelial growth factor (VEGF) expression [23].