Activation of these TLRs on airway epithelial cells (AECs) leads to increased chemokine synthesis, such as IL-8 (CXCL8), and subsequent neutrophil recruitment to sites of infection (Greene et al., 2005; Bérubé et al., 2009; Beaudoin et al., 2013). The gene discussed is CXCL8; the disease is infection.