A previous report (106) asserted that no correlation exists between recipients’ autoimmunity and graft function posttransplant, but others have stated that 60% of islet transplantation recipients with fewer autoreactive circulating GAD65 T cells achieved long-term insulin independence, whereas the 40% of patients with elevated levels of autoreactive GAD65-specific T cells producing proinflammatory cytokines and did not achieve long-term insulin independence (108). The gene discussed is GAD2; the disease is Autoimmunity.