IFNG and asthma: Increased expression of IFN-gamma producing CD8+ T cells has been demonstrated in subjects with asthma (12, 34), although a decreased expression of IFN-gamma in CD8+ T cells in atopic asthmatic patients has also been described (35) and CD8+ T cells from atopic asthmatic subjects have been shown to contain more IL-4 than those from non-atopic donors (29).