Assigning differentially expressed genes to functional groups revealed that numerous stress-related signaling pathways were activated in the liver and kidney under ED and HD conditions (Table 2), such as ERK/MAPK, mTOR, glucocorticoid receptor, SAPK/JNK, and JAK/Stat signaling, as well as p38 and p53 signaling. This evidence concerns the gene MAPK8 and Huntington disease.