Assigning differentially expressed genes to functional groups revealed that numerous stress-related signaling pathways were activated in the liver and kidney under ED and HD conditions (Table 2), such as ERK/MAPK, mTOR, glucocorticoid receptor, SAPK/JNK, and JAK/Stat signaling, as well as p38 and p53 signaling. The gene discussed is NR3C1; the disease is Huntington disease.