IFNB1 and melanoma: The constitutive lack of endogenous IFN-β (Ifnb1−/− mice) as well as the lack of type I IFN signaling (Ifnar1−/− mice) leads to increased growth of different types of tumors (B16F10 melanoma, 4T1 mammary carcinoma, LLC carcinoma, and MCA205 fibrosarcoma) (8, 18, 20, 34, 69) and enhanced metastatic processes (20).