A case-controlled study including 160 patients with MS and 150 healthy controls revealed the protective role of TT genotype of TaqI (ORs| < |1), CC genotype of Apal, and GG genotype of BsmI (ORs| < |1), suggesting that VDR polymorphisms seem to have a notable connection with MS pathogenesis; however, studies in big population that analyze the functional work on the gene structure and its function are needed (109). The gene discussed is ST8SIA6-AS1; the disease is myeloid sarcoma.