CD8A and neoplasm: Moreover, NK-like CD8+ T-cells from Epstein–Barr virus (EBV)-associated tumor patients are quantitatively and functionally impaired and in a human-thymus-SCID chimera model, the EBV-induced human NK-like CD8+ T-cells synergize with NK-like CD4+ T-cells suppressing EBV-associated tumors upon induction of a Th1-bias (43).