In a report published by Novais et al. (2012) considering ertapenem resistance in Enterobacteriaceae, the authors indicated two mechanisms of OM permeability disruption, namely, nonsense mutations and/or insertion sequence (IS) incorporation into structural porin-encoding genes, and production of nonfunctional proteins effecting from mutations in the third loop region of the transmembrane channel. Here, VDAC1 is linked to ocular melanoma.