Conversely, in an interventional study, we reported that in individuals with hypertension and type 2 diabetes, plasma renin activity level was significantly higher with habitual “low” sodium intake (mean 24-h urinary sodium excretion of 126 mmol/24 h) than with habitual high sodium intake (mean 24-h urinary sodium excretion of 256 mmol/24 h) (73). The gene discussed is REN; the disease is Hypertension.