REN and hypertensive disorder: In contrast, He and MacGregor (23) reported that there was only a small increase in plasma renin activity and plasma aldosterone with modest sodium restriction over a longer period (≥4 weeks) in individuals with hypertension (median 24-h urinary sodium reduction of 78 mmol/24 h) and individuals with normotension (median 24-h urinary sodium reduction of 74 mmol/24 h).