The two main neuropathological characteristics of AD have been recognized, namely senile plaques (SPs) and neurofibrillary tangles (NFTs), which are, respectively, associated to amyloid β (Aβ) peptides and hyperphosphorylated tau protein (Holtzman et al., 2011; Marsden et al., 2011). Here, MAPT is linked to Alzheimer disease.