Third, in addition to treatment of osteoporosis and prevention of breast cancer in post-menopausal women (Gizzo et al., 2013), RAL has been shown to produce neuroprotective (Ishihara et al., 2015) and beneficial cardiometabolic effects (Dayspring et al., 2006), as well as improve cognition in both male and female schizophrenic patients (Kindler et al., 2015). This evidence concerns the gene RALA and breast cancer.