For example, tamoxifen use in humans (Yang et al., 2013) and research of CBR inverse agonists demonstrate that both groups of compounds increase bone mineralization, sensitivity to nociception and may result in depression (Idris and Ralston, 2010; Buggy et al., 2011; Nazarali and Narod, 2014; Azizi-Malekabadi et al., 2015). This evidence concerns the gene CNR1 and major depressive disorder.