According to the data from the ROCKET AF study (Prevention of Stroke and Embolism Trial in Atrial Fibrillation), the presence of combined CYP3A4/5 and P-gp inhibitors did not have any impact on safety outcomes such as bleeding events when comparing the rivaroxabanand warfarin groups (Piccini et al., 2016). Here, CYP3A4 is linked to atrial fibrillation.