MAPT and tauopathy: On the one side, neuroinflammation has been implicated in driving hyperphosphorylation and aggregation of tau and neurodegeneration in humans (Gebicke-Haerter, 2001; Ishizawa and Dickson, 2001; Bellucci et al., 2011) and various models of tauopathies (Bellucci et al., 2004; Zilka et al., 2009).