TDP-43-WT mice displayed a significant increase in the percentage of open arm entries (Student’s t test, t(28) = 2.280 p = 0.0304; Figures 5B,C) and a non-significant trend towards increased percentage of time in the open arms (Student’s t test, t(28) = 1.459 p = 0.1557, Figure 5D), suggesting decreased anxiety-like behavior compared to the control group. The gene discussed is TARDBP; the disease is Anxiety.