Importantly, total exploration time in the social side showed non-significant differences, indicating that the decrease in social interaction time is not due to perception of the stimulus as aversive, increased anxiety-like behavior or decreased exploratory drive (254.4 ± 21.3 s vs. 201.3 ± 18.7 s for control and TDP-43-WT12 mice, respectively; t(27) = 1.717, p = 0.0974). The gene discussed is TARDBP; the disease is Anxiety.