TARDBP and amyotrophic lateral sclerosis: Subsequent in-depth behavioral analysis of inducible TDP-43-ΔNLS mice demonstrated an early establishment of motor, cognitive and social abnormalities (Alfieri et al., 2014), of relevance since these three behavioral domains are affected in patients with different presentations within the clinicopathological spectrum of FTD/ALS (Giordana et al., 2011; Seltman and Matthews, 2012; Gordon, 2013).