Our previous studies have found that FtMt overexpression in neuroblastoma SH-SY5Y cell increased its resistance to oxidative stress (Shi et al., 2010; Wu et al., 2013), indicating FtMt is not only involved in storing cellular iron, but may also play a role in protecting mitochondria from iron-dependent oxidative damage (Yang et al., 2013; Gao and Chang, 2014). The gene discussed is FTMT; the disease is neuroblastoma.