MAPT and Alzheimer disease: AD and other tauopathies are progressive supranuclear palsy (PSP), linked to chromosome 17 Parkinson, frontotemporal dementia and cerebral ischemia, are characterized by a phenomenon of hyperphosphorylation of tau protein, causing changes in the microtubule (MT) assemblying-disassemblying dynamics (Avila et al., 2004).