MAPT and Cerebral ischemia: However, CDK5 silencing in the hippocampus of ischemic rats has very impacting benefits, because it reverses learning and relearning impairment caused by cerebral ischemia, correlated with the prevention of neuronal loss, decreased hyperphosphorylated tau, reactive astroglia and microglia, within a month of post-ischemia/reperfusion (Gutiérrez-Vargas et al., 2015b).