APP and Cerebral ischemia: Several studies have demonstrated presence of senile plaques (βA) and amyloid precursor protein (APP) in close proximity to the ischemic focus (Ikeda et al., 2000; Shi et al., 2006), suggesting a degree of convergence in the neuropathogenesis of cerebral ischemia and AD (Zekry et al., 2003; Snyder et al., 2015; Kalaria et al., 2016; Nelson et al., 2016).