Numerous transgenic animal models for PD have been generated, mostly carrying mutations in genes associated with monogenic PD such as alpha-synuclein, leucine rich repeat kinase 2 (LRRK2), Parkin, PTEN-induced putative kinase 1 (PINK1), and protein deglycase DJ-1 (reviewed by Lee et al., 2012). This evidence concerns the gene PRKN and Parkinson disease.