PRNP and Stroke: Strikingly, HIF-1α expression is significantly decreased in Prnp-/- and increased in Prnp+/+ mice at 24 h post-stroke (Doeppner et al., 2015) suggesting that PrPc might exert its neuroprotective effects against hypoxic damage in vivo via direct or indirect regulation of HIF-1α and hence LDH-A/lactate.