Toll-like receptor 4 (TLR4), nerve growth factor IB (Nur77) and Nuclear receptor related 1 (Nurr1) played a critical role in the induction of neuroinflammatory responses in PD model (Gao et al., 2016; Wei et al., 2016; Zhou et al., 2016). Here, NR4A2 is linked to Parkinson disease.