Sod1 knockout (Sod1) mice exhibit various aging phenotypes that include retinal degeneration and vision loss, cochlear hair cell degeneration and hearing loss, accelerated motor neuron degeneration after axonal injury and exacerbated memory loss and amyloid deposition when crossed to a mouse model of Alzheimer’s disease (AD), raising the possibility that SOD1 may play an important neuroprotective role (Behndig et al., 2001; Imamura et al., 2006; Hashizume et al., 2008; Murakami et al., 2011, 2012; Kojima et al., 2012; Saccon et al., 2013). Here, SOD1 is linked to early-onset autosomal dominant Alzheimer disease.