ASCL1 and neuroblastoma: One such important post-transcriptional regulator of hASH1 expression is the heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and its role has been described in neuroblastoma cells exposed to hypoxia, indicating that low oxygen tension could be an important determinant of neuroendocrine development and tumor development (Kasim et al., 2014).