This is in contrast to the results from Hoybergs and Meert, which demonstrated that low-dose insulin delivered through subcutaneous insulin pellet can nearly normalize diabetes-induced tactile allodynia and mechanical hyperalgesia, despite persistent hyperglycemia (blood glucose levels dropped from 600 mg/dl to approximately 400 mg/dl 2 weeks after insulin pellet insertion; Hoybergs and Meert, 2007). The gene discussed is INS; the disease is diabetes mellitus.