Due to the positive association between IL‐17 and INF‐γ, the increase in INF‐γ in the serum of SLE patients reasonably upregulated the IL‐17 expression and it has been shown that IL‐17 plays an important role in various autocrine diseases, including SLE and rheumatoid arthritis 30, 31. The gene discussed is IL17A; the disease is rheumatoid arthritis.