TCF7 and systemic lupus erythematosus: TCF7 has been implicated in Type 1 Diabetes risk (71), but there is only weak LD (r2 < 0.4) between the reported missense variant and SLE risk SNP rs7726414 (19 kb upstream of TCF7) or any protein-coding variants of TCF7, suggesting in SLE the causal mechanism may be dysregulation of expression of TCF7 rather than a missense change.