Other renewable in vitro models such as HepaRG (a hepatoma-derived cell line) and Fa2N4 (an immortalized human hepatocyte cell line) have been tested as substitutes for primary human hepatocytes for modeling CYP3A4 induction DDI (Ripp et al., 2006; Kanebratt and Andersson 2008). This evidence concerns the gene CYP3A4 and hepatocellular carcinoma.