Death receptor 3 (DR3; TNFRSF25, TRAMP, LARD, Apo3 and Wsl1) is involved in the pathogenesis of multiple inflammatory conditions such as inflammatory bowel disease, atherosclerosis, allergic lung inflammation and RA [14], [16], [17], [18], [19], [20]. The gene discussed is TNFRSF25; the disease is rheumatoid arthritis.