In an addition, PTEN, another most commonly mutated tumor suppressor in humans, negatively regulates PI3K and mTORC1 through catalyzing phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3), and thus possibly involves in CPT inhibition of mTORC1. Here, PTEN is linked to neoplasm.