Yan et al. [26] evaluated 336 patients with DLBCL by immunohistochemistry and FISH, and found a high specificity (approximately 90%) of positivity for Myc and Bcl2 in the immunohistochemistry in relation to FISH positivity for MYC and BCL2 translocations, favoring its potential use for stratification in cases of DLBCL with aggressive behavior [26]. This evidence concerns the gene BCL2 and diffuse large B-cell lymphoma.