A meta-analysis of several expression data sets [16, 48–50] identified and validated a 3-gene model (TNFRSF8, BATF3, and TMOD1) able to separate ALK negative ALCL from PTCL-NOS with a 97% accuracy [18]. The gene discussed is TNFRSF8; the disease is mature T-cell and NK-cell non-Hodgkin lymphoma.