One of the first CGH studies in ALCLs and PTCL-NOS identified recurrent chromosomal gains of 1q (1q41-qter) in 46%, and losses of 6q (6q21) and 13q (13q21-q22) in 31% and 23% ALK negative ALCL patients, respectively [65]. Here, ALK is linked to mature T-cell and NK-cell non-Hodgkin lymphoma.