SERPINF1 and neoplasm: Following such studies, novel candidates emerged, such as:caveolins 1 and 2 for disease progression [80], MIC-1 related with tumor progression and low survival [81, 82], complement proteins, to differentiate between malignant and begnin PCA, Pigment epithelium-derived factor (PEDF) as early stage predictor of malignancy [83, 84].