ProMark® (Metamark Genetics, Inc, Cambridge, MA) is a tissue test with prognostic value for PCa aggressiveness; detects a 8-proteins signature (DERL1, CUL2, SMAD4, PDSS2, HSPA9, FUS, pS6 (phosphorylated S6), YBOX1), not influenced by sampling error [17]. Here, SMAD4 is linked to posterior cortical atrophy.