Another recent study observed that the CHD protective A allele of rs72664324 at the PPAP2B locus increases the transcriptional enhancer response to oxidized low-density lipoprotein in macrophages, which results in an alteration in LPP3 activity, and in turn promotes increased metabolism of pro-inflammatory mediators within atherosclerosis lesions [12]. This evidence concerns the gene PLPP3 and atherosclerosis.