TP53 and infection: The qRT-PCR assay further showed that the level of DRAM mRNA in H1299-Δ40p53 cells was significantly lower than that of H1299 cells in response to MMS plus rAd-p53 infection, suggesting that Δ40p53 inhibits the transactivation activity of wtp53 in inducing DRAM expression (Figure 7E).