Differences in expression between carcinoma and normal mucosa, or differential miRNA expression by genotype, was associated with six SNPs, SMAD3 rs12708492, BMPR2 rs228545, and NFκB1 rs230510, SMAD3 rs2414937, NFκB1 rs3821958, and RUNX3 rs6672420 (Table 4) for colorectal cancer overall. The gene discussed is SMAD3; the disease is colorectal cancer.