KEAP1 and cancer: In order to independently validate the specific correlation of data obtained to the ccRCC histotype, the KEAP1 methylation and the functional effect of KEAP1 promoter methylation on its expression was analyzed in two independent datasets of 481 ccRCC and 265 PRCCs cancer samples available from The Cancer Genome Atlas portal (TCGA), (for ccRCC cohort characteristics see additional Supplementary Table 2).