The KEAP1 methylation level was firstly evaluated on DNA obtained from a total of 89 RCC tissues, 70 paired normal renal tissues distant from the tumors (NRDT) and 10 normal renal tissues from patients affected by urothelial carcinoma (NR), (Supplementary Figures 2 and 3). Here, KEAP1 is linked to renal cell carcinoma.