MTOR and colorectal cancer: Specifically, gene expression profiling can measure genome-wide gene expression activity that can be used to identify discrete biologically relevant phenotypes to characterize a disease.[18, 25] This can then be used to characterize phenotypes such as response to drugs to help guide existing therapies and discover new therapeutic targets.[26–28] Thus, in our current work, we used gene expression profiling to identify signaling pathways that are activated upon treatment with oxaliplatin in colorectal cancer and discovered that the mTOR pathway was one such pathway.