NR1H4 and Multiple Organ Failure: This apparent association was put to the test by pretreating animals with OCA, an oral FXR-agonist, prior to induction of IRI, which not only protected against IRI-mediated epithelial cell loss (and thus preservation of mucosal integrity and function) but also blocked endotoxin translocation and an overzealous pro-inflammatory cascade leading to multiple organ failure and death (Fig 7).