While early translational studies were focused on the central role of FXR as a chief regulator of bile acid and lipid metabolism, the hepatic involvement of FXR and the beneficial effects of FXR agonists on hepatic inflammation and fibrosis were subsequently illustrated in both animal models of non-alcoholic fatty liver disease and toxic cirrhosis, amongst others [23–26]. The gene discussed is NR1H4; the disease is metabolic dysfunction-associated steatotic liver disease.