Isobavachalcone could significantly inhibit the transcription of IL-6 and IL-1β in PD mouse (Fig 3A), it also decreased the transcriptional levels of TNF-α, IL-6, IL-1β, and IL-10 in BV-2 cells stimulated by LPS (Fig 3B–3E). The gene discussed is IL1B; the disease is Parkinson disease.