Blood TDPase and TMPaseactivities were significantly increased in AD patients as compared with those in control subjects (TDPase: 1.24 ± 0.08vs. 1.00 ± 0.04, P < 0.05, Fig 1A; TMPase: 1.22 ± 0.04 vs. 1.00 ± 0.06, P < 0.01, Fig 1B). Here, ACP3 is linked to Alzheimer disease.