The authors of the one other study using LOXL4-knockdown MDA-MB-231 cells concluded that LOXL4 knockdown did not affect primary MDA-MB-231 cell tumor growth, but decreased spontaneous metastasis of MDA-MB-231 cells to the lungs in SCID and non-obese diabetic-SCID mice. This evidence concerns the gene LOXL4 and neoplasm.